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Majewski Lab, McGill University

Positions available - NEW Winter 2013!!!

About

Genomic Approaches to Understanding Human Disease.

We develop analytical methods to tackle a diverse set of problems in human genetic disease. The datasets are predominantly based on massively parallel sequencing, and include whole genome and exome sequencing, transcriptome sequencing, ChIPSeq, and methylation data. We apply the approaches to Mendelian disease, polygenic disease, and cancer. Member of our lab actively collaborate with clinicians at McGill, throughout Canada, and worldwide.

Using bioinformatics approaches to understand gene-splicing regulation.

RNA processing is emerging as a key mechanism in modifying gene expression. Our research is based on the intersection of bioinformatics and experimental approaches. We are using massively parallel sequencing data to detect variations in RNA processing, such as alternative-splicing, polyadenylation, RNA editing, along with statistical analyses aimed at elucidating nucleotide sequencing responsible for regulating those processes.

Members of our group are also interested in evolutionary issues such as determination of mutation rates, recombination rates and detection of selective pressures in eukaryotic genomes. We find that questions related to evolution and function are intrinsically intertwined and that the investigation of the two issues benefits from joint consideration.

Our lab is located at the McGill University and Genome Quebec Innovation Centre in Montreal, Quebec, Canada.

Positions available - NEW Winter 2013!!!

3 post-doctoral or reseach assistant/associate position immediately available:

- Bioinformatician/Computational Biologist (1) to develop and implement methods for integration of Genomic data: RNASeq, MethylCSeq, ChIPSeq, genome DNA. The main application will be in the field of cancer biology and the principal aim is to understand downstream genomic consequences of distinct driver mutations in pediatric glioblastoma. There will also be ample opportunities to work on other cancers and related datasets.

- Bioinformatician/Computational Biologist (2) to maintain and further develop computational pipelines for analysis of human exome and genome sequencing data. The main field of application is rare Mendelian disease, but the tools will gradually be extended to tackle polygenic and complex diseases, as well as establishing variant databases. Another aspect of the project may involve establishing standards for implementation of clinical exome/genome sequencing.

- Senior Molecular Laboratory Researcher (3). The candidate will be responsible for implementing state of the art molecular gene targeting methods - such as TALENs or CRISPR - to manipulate cancer cell lines and xenografts, in order to dissect the effects of distinct driver mutations in pediatric glioblastoma. Once established, the approaches will be applicable to a wide range of cancers.

The positions are funded by recently awarded Genome Canada grants, and will be available for upto four years. All positions involve high levels of collaboration between scientists at the Genome Centre and clinical researchers in Montreal and world-wide. PhD preferable, but MSc level applicants with appropriate experience may be eligible. Salary negotiable depending on experience. To apply, send CV to jacek.majewski (at) mcgill.ca

Affiliations

Mailing Address

Jacek Majewski
McGill University and Genome Quebec Innovation Centre
740 Dr. Penfield Ave, Room 7210
Montreal, QC Canada H3A 1A4
  • Tel: 514-398-3311 ext. 00891
  • Email: <jacek.majewski AT NOSPAM mcgill DOT ca>

Home (last edited 2013-02-07 10:16:25 by JacekMajewski)